Study: Life After Pediatric Sepsis Evaluation (LAPSE)

Study Type: Observational
Study Period: February 2014 – June 2017
Enrollment: 392 
Consent: Yes

Purpose:

The purpose of this prospective observational study is to describe short and long-term outcomes among a moderate cohort of children surviving septic shock. In contrast to adult medicine, little is known about the long term outcomes following pediatric sepsis. For the first time LAPSE will investigate the intensity and duration of sepsis-associated morbidity that persists in the weeks and months following the acute septic event. LAPSE will describe the post sepsis illness trajectory through serial measurements of Health Related Quality of Life (HRQL) and subject functional status (FS). In addition LAPSE will examine organ dysfunction, as well as individual and environmental characteristics that may influence these outcome measures.

We hypothesize that significant variation of HRQL and functional status will be observed following survival of severe sepsis, enabling development of suitable composite outcome measures for future interventional trials of pediatric sepsis. We further hypothesize that deterioration of HRQL and functional status following survival of severe sepsis will correlate with (1) the intensity and duration of specific organ failures that adversely affect systemic oxygen delivery and consumption during the acute illness; and (2) characteristics of the individual (chronic co-morbid conditions, personality traits) and environment (socioeconomic factors, family dynamics and parental stress).

 

 

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