Study: The Critical Illness Stress-induced Immune Suppression (CRISIS) Prevention Trial

Study Type: Interventional
Study Period: April 2007- November 2009
Enrollment: 293
Consent: Yes


Despite use of CDC recommended preventive strategies, nosocomial infection / sepsis occurs in up to 40% of children requiring long stay intensive care. Since lymphopenia and protein malnutrition are known risk factors, we evaluated whether directed nutriceutical supplements would reduce nosocomial infection / sepsis.  A multicenter randomized double-blinded comparative trial was conducted to determine if enteral zinc, selenium, glutamine and IV metoclopramide (ZSGM) would reduce nosocomial infection / sepsis compared with enteral whey protein (WHEY) and IV placebo, when administered for up to 28 days of Pediatric Intensive Care Unit (PICU) stay.

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